This IBA extends along the Sandusky River riparian corridor from Upper Sandusky north to Fremont, the entire river flowing 130 miles from its source
in Crawford County to the Muddy Creek and Sandusky Bay. It is designated a State Scenic River and is the largest, cleanest riverine system in Northwest Ohio, with many scenic exposed dolomite and limestone outcroppings. The southern two-thirds is relatively flat, characterized by broken ridges (glacial end moraines) ranging from 10 to 50 feet in height. The northern one-third is flat to gently rolling, comprising remnants of the shorelines of ancient glacial lakes.
The river corridor is an important flyway for huge numbers of waterfowl heading for Sandusky Bay. It is notable for its concentration of nesting and wintering Bald Eagles. Kirtland's Warbler has been recorded in spring migration and large numbers of migrant landbirds use the corridor.
Pollution and development both pose threats to this river.